
Common name: Amaryllis Lily
Botanical name: Hippeastrum hybrid Family: Amaryllidaceae (Nargis family)
________________________________________
Hippeastrum is a genus of about 70-75 species and 600+ hybrids and cultivars of bulbous plants in the family Amaryllidaceae, native to tropical and subtropical regions of the Americas from Argentina north to Mexico and the Caribbean. Some species are grown for their large showy flowers. These plants are popularly but erroneously known as Amaryllis, which is an African genus, in the same family. "Hippeastrum" is Latin for "horseman's star" (also known today as "knight's star") and was chosen in 1837 by the Honorable Reverend William Herbert, Dean of Manchester. No one is entirely sure why he picked this name although buds on the verge of opening do look something like a horse's ear and clearly the blossoms do resemble six-pointed stars. Colors include red, rose, pink, white, orange, yellow and pale green with variations on these including different colored stripes and edges on the petals. Some flowers have uniform colors or patterns on all six petals while others have more pronounced colors on the upper petals than on the lower ones.
The plant lectins derived from Galanthus nivalis (Snowdrop) (GNA) and Hippeastrum hybrid (Amaryllis)(HHA) selectively inhibited a wide variety of human immunodeficiency virus type 1 (HIV-1) and HIV-2 strains and clinical (CXCR4- and CCR5-using) isolates in different cell types. They also efficiently inhibited infection of T lymphocytes by a variety of mutant virus strains. GNA and HHA markedly prevented syncytium formation between persistently infected HUT-78/HIV cells and uninfected T lymphocytes. The plant lectins did not measurably affect the antiviral activity of other clinically approved anti-HIV drugs used in the clinic when combined with these drugs. Short exposure of the lectins to cell-free virus particles or persistently HIV-infected HUT-78 cells markedly decreased HIV infectivity and increased the protective (microbicidal) activity of the plant lectins. Flow cytometric analysis and monoclonal antibody binding studies and a PCR-based assay revealed that GNA and HHA do not interfere with CD4, CXCR4, CCR5, and DC-SIGN and do not specifically bind with the membrane of uninfected cells. Instead, GNA and HHA likely interrupt the virus entry process by interfering with the virus envelope glycoprotein. HHA and GNA are odorless, colorless, and tasteless, and they are not cytotoxic, antimetabolically active, or mitogenic to human primary T lymphocytes at concentrations that exceed their antivirally active concentrations by 2 to 3 orders of magnitude. GNA and HHA proved stable at high temperature (50°C) and low pH (5.0) for prolonged time periods and can be easily formulated in gel preparations for microbicidal use; they did not agglutinate human erythrocytes and were not toxic to mice when administered intravenously.


